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Efficacy of Targeted Memory Reactivation (TMR) Training During Sleep for Obsessive-Compulsive Disorder

Efficacy of Targeted Memory Reactivation (TMR) Training During Sleep for Obsessive-Compulsive Disorder

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500100976
Enrollment
Unknown
Registered
2025-04-17
Start date
2024-08-28
Completion date
Unknown
Last updated
2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obessive compulsive disorder

Interventions

Experimental Group:Reactivating counter-OCD training by playing associated sounds during sleep
Control group :Playing white noise during sleep

Sponsors

West China Hospital, Sichuan University.
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) Initial diagnosis of obsessive-compulsive disorder by DSM-5; All obsessive-compulsive disorder participants reported the predominant symptoms of pollution fear, washing, and cleaning, meeting criteria for pollution-related obsessive-compulsive disorder subtype (C-OCD); (2) Yale-Brown Obsessive-Compulsive Disorder Scale (Y-BOCS) score 8-31; (3) Age 18-60 years old; (4) Basic computer operation ability; (5) the ability to provide informed consent.

Exclusion criteria

Exclusion criteria: (1) Have changed any psychotropic drugs within 6 weeks before the experiment; (2) comorbid psychiatric disorder or substance use disorder that may affect treatment (e.g., severe personality disorder or psychosis); (3) are receiving psychotherapy for obsessive-compulsive disorder or anxiety disorder; (4) patients with hearing impairment; (5) Recent suicidal attempts or active suicidal ideation; (6) Overnight shift within 6 weeks before the experiment or combined with factors or diseases that affect sleep, such as insomnia, OSA, etc.; (7) Severe cardiopulmonary diseases, liver and kidney diseases, etc.

Design outcomes

Primary

MeasureTime frame
Reaction time of counter-OCD training;

Secondary

MeasureTime frame
Yale-Brown Obsessive Compulsive Scale score, Y-BOCS score;Hamilton Anxiety Rating Scale (HAM-A) score;Pittsburgh Sleep Quality Index;

Countries

China

Contacts

Public ContactRong Ren

West China Hospital, Sichuan University.

498880651@qq.com+86 189 8060 5572

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026