None
Conditions
Interventions
Group A(1~3 years old):Intravenous injection of pentethylquine hydrochloride 0.01 mg/kg, sufentanil 0.3 µg/kg, 1 min, and cyclopofol were administered at an initial dose of 0.6 mg/kg for 30 seconds. T
2) No other sedative drugs are used. A maximum of three insertion attempts are allowed before endotracheal intubation is performed. According to the top-down sequential allocation method, cyclopofol w
Group B(4~6 years old):Intravenous injection of pentethylquine hydrochloride 0.01 mg/kg, sufentanil 0.3 µg/kg, 1 min, and cyclopofol were administered at an initial dose of 0.6 mg/kg for 30 seconds. T
2) No other sedative drugs are used. A maximum of three insertion attempts are allowed before endotracheal intubation is performed. According to the top-down sequential allocati
Sponsors
Women and Children's Medical Center Affiliated to Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Children undergoing laryngeal mask general anesthesia, ASAI-II, regardless of gender; 2. Age: 1-6 years old; 3. Body weight 8~25 kg, BMI<30 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Children allergic to cyclopofol and opioid ingredients; Children with severe thrombocytopenia and gastrointestinal ulcers. 2. Analgesic and sedative drugs, antiemetic drugs and anti-pruritus drugs were used 24 hours before surgery; 3. Children with symptoms of acute upper respiratory tract infection before surgery; 4. Children with a history of bronchial asthma; 5. Children with severe sleep apnea syndrome and arrhythmia; 6. History of recovery from abnormal surgical anesthesia; Preoperative assessment of the presence or potential presence of difficult airways; 7. Renal function impairment (BUN and/or Cr> upper limit of normal); Liver function impairment (ALT and/or AST>1.5 times the upper limit of normal) 8. Children with related mental and neurological diseases who are difficult to evaluate the analgesic effect; 9. Children with a history of chronic pain or long-term use of painkillers; 10. Children with other conditions deemed unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ciprofol unconscionable ED50 in children;Ciprofol unconscionable ED95 in children; | — |
Countries
China
Contacts
Public ContactHuang Yaying
Guangzhou Women and Children Medical Center/Women and Children's Medical Center Affiliated to Guangzhou Medical University
Outcome results
None listed