Postoperative delirium
Conditions
Interventions
Bupivacaine hydrochloride combined with general anesthesia group:TAP block was performed with Bupivacaine hydrochloride
Bupivacaine liposome combined with general anesthesia group:TAP block was performed with bupivacaine liposomes
General anesthesia group:placebo
Sponsors
Hebei General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Age >=65 years old; 2.Patients undergoing elective laparoscopic major abdominal surgery; 3.ASA Grade II-III; 4.No preoperative use of drugs that might have serious effects on the cardiovascular system, and no history of psychoactive substance dependence; 5.Preoperative mini-Mental State Scale (MMSE) score >=24;
Exclusion criteria
Exclusion criteria: 1.People who are allergic to bupivacaine liposomes or other narcotic drugs used in this study; 2.There is cardiac insufficiency, including degree II to III atrioventricular block or atrial fibrillation; 3.Combined with severe hypertension, coronary heart disease, bronchial asthma history, or serious liver and kidney damage; 4.With diabetes, pheochromocytoma, hyperthyroidism, Cushing's syndrome and other metabolic disorders; 5.There is infection, inflammation or injury at the TAPB puncture site; 6.Mental disorders caused by psychoactive substances or non-addictive substances, organic mental disorders and other mental disorders;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| The severity of postoperative delirium;pain score;PI;The severity of postoperative brain function injury; | — |
Countries
China
Contacts
Public ContactLi Jianli
Hebei General Hospital
Outcome results
None listed