Frailty
Conditions
Interventions
Group A:Part 1:sedentary for 8 hours?Part 2:interrupting sedentary time with 3-min moderate to high-intensity walking bouts every 30 minutes ?Part 3:interrupting sedentary time with 3-min resistance
Group B: Part 1:interrupting sedentary time with 3-min moderate to high-intensity walking bouts every 30 minutes?Part 2: sedentary for 8 hours?Part 3:interrupting sedentary time with 3-min resistance
Sponsors
School of Nursing and Rehabilitation, Shandong University
Eligibility
Sex/Gender
Female
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Participants must meet all of the following criteria to be included in the study: 1. Frail women over 65 years old living in the community; 2. Sedentary time of >=8 hours per day; 3. No dementia, cognitive impairment, or symptomatic mental disorders, and able to communicate normally with others. 4. Have not participated in any other clinical trials in the 6 months prior to enrollment.
Exclusion criteria
Exclusion criteria: Subjects will be excluded if they have any of the following characteristics: 1. Have contraindications to exercise: severe cardiovascular and renal disease or have any symptoms or signs related to cardiovascular disease; 2. Inability to assess muscle strength or use assistive devices to walk; 3. Take a large amount of antibiotics or Chinese herbal medicines within 1 month 4. History of heavy drinking within 1 month, or long-term history of heavy drinking abuse; 5. Have obvious cold symptoms such as fever within 1 month; 6. Severe diarrhea, vomiting and other symptoms within 2 weeks; 7. Obvious symptoms of anemia in the near future, such as hypoglycemic syncope.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proteome changes;Metabolomic changes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Rate Variability;Postprandial Blood Glucose Changes; | — |
Countries
China
Contacts
Public ContactSi Chen
School of Nursing and Rehabilitation, Shandong University
Outcome results
None listed