None
Conditions
Interventions
R1 Group:Remimazolam 0.10 mg/kg is given for anesthesia induction.
R2 Group:Remimazolam 0.15 mg/kg is given for anesthesia induction.
R3 Group:Remimazolam 0.20 mg/kg is given for anesthesia induction.
R4 Group:Remimazolam 0.25 mg/kg is given for anesthesia induction.
R5 Group:Remimazolam 0.30 mg/kg is given for anesthesia induction.
R6 Group:Remimazolam 0.35 mg/kg is given for anesthesia induction.
R7 Group:Remimazolam 0.40 mg/kg is given for anesthesia induction.
Sponsors
Weifang People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Patients who choose to undergo hysteroscopy, cervical conization, or other gynaecological day surgery at our hospital. 2. ASA classification I-II. 3. Females aged 18-64 years. 4.Sign the informed consent for anesthesia.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to benzodiazepines and any components of this product. 2. Patients with myasthenia gravis. 3. Patients with schizophrenia and severe depression. 4. Pathological obesity/obstructive sleep apnea. 5. Acute upper respiratory tract infection. 6. Asthma attack period. 7. Uncontrolled severe hypertension. 8. Unstable angina. 9. Severe liver dysfunction. 10. Acute upper gastrointestinal bleeding with shock. 11. Severe anemia. 12. Gastrointestinal obstruction with retention of gastric contents. 13. Long-term sedative and analgesic drug use history and allergic history. 14. There are contraindications to anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ai index 2 min after anesthesia induction;Change in Ai in 5 minutes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Induction period and intraoperative incidence of adverse events;Anesthesia maintenance and recovery time;General information of the patient;Changes in hemodynamics during anesthesia;Intraoperative Ai indicators;Reimazolam and alfentanil dosage; | — |
Countries
China
Contacts
Public ContactFanceng Ji
Weifang People's Hospital
Outcome results
None listed