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Study on the effect of different gingival phenotypes on widening of keratinized gingiva with heterologous collagen matrix

Study on the effect of collagen on widening peri-implant keratinized tissue by gingival thickness in the recipient area

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500100933
Enrollment
Unknown
Registered
2025-04-17
Start date
2022-07-04
Completion date
Unknown
Last updated
2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insufficient width of keratinized gingiva

Interventions

Thin gingival group:Widening of keratinized gingiva using xenogeneic collagen matrix.
Thick gingival group:Widening of keratinized gingiva using xenogeneic collagen matrix.

Sponsors

Beijing Haidian Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Subjects were aged between 18 and 60 years and in good general health; 2.The width of residual keratinized gingiva on the buccal side of surgical region was less than 2 mm; the surgical region did not exceed 3 teeth; 3.The need for additional keratinized mucosa for aesthetic or functional reasons; 4.Good oral hygiene; O'Leary oral plaque index < 20%.

Exclusion criteria

Exclusion criteria: 1.Smoking; 2.Systemic diseases or pregnancy; 3.Untreated periodontal disease and failure to maintain good plaque control; 4.History of mucogingival surgery in the surgical area; 5.Allergy to collagen; 6.Use of drugs (immunosuppressants, phenytoin or any other drugs that may affect mucosal healing); 7.Participants have participated in other clinical studies in the past six months.

Design outcomes

Primary

MeasureTime frame
Width of keratinized gingiva;

Secondary

MeasureTime frame
Keratinized gingival thickness;Graft shrinkage;

Countries

China

Contacts

Public ContactRuiyong Wang

Beijing Haidian Hospital

wangruiyong@163.com+86 135 2133 6262

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 5, 2026