Carbapenem-Resistant Klebsiella pneumoniae Infectio
Conditions
Interventions
Fecal microbiota transplantation group:Fecal microbiota transplantation is performed once every other day for three times.
Standard treatment group:Antibiotic treatment
Sponsors
The First People's Hospital of Yunnan Province
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult patients (>=18 years of age at enrollment) 2. Patients received positive CRKP from rectal swabs within 1 week before the trial. 3. Participants or legal representatives must be able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Life expectancy is three months or less. 2. Pregnancy or lactation. 3. Patients who are unable/unwilling to participate in the study. 4. History of colectomy, colostomy or ileostomy. 5. Severe immunodeficiency (1) Systemic chemotherapy = 60 mg/day for >=30 days) or other immunosuppressive drugs (4) Neutropenia, absolute neutrophil count <1000/µL, (5) Solid organ transplant recipients (6) Recipients of hematopoietic stem cell transplantation (7) Other causes of severe immunodeficiency. 6. Clinical symptoms and signs of mucositis. 7. Major abdominal surgery within the upcoming 30 days. 8. Severe drug or food allergies. 9. Anatomical contraindications for nasogastric tube placement. 10. Unable to obtain a compatible FMT preparation (regarding donor/recipient CMV, EBV and toxoplasmosis serology). 11. Judged by the investigator as not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clearance of carbapenem-resistant Klebsiella pneumoniae; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of carbapenem-resistant Klebsiella pneumoniae infection.; | — |
Countries
China
Contacts
Public ContactChen Guobing
The First People's Hospital of Yunnan Province
Outcome results
None listed