Postoperative Cognitive Dysfunction
Conditions
Interventions
Propofol group:Propofol was used instead of sevoflurane before the end of operation
Sevoflurane group:Sevoflurane and remifentanil were used throughout the whole process, and the anesthetic medication management during the maintenance period was the same as that of the propofol group
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
66 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age greater than 65 years old; 2. American Society of Anesthesiologists (ASA) Physical Status I-III; 3. Primary school education or above; 4. Negative bell painting test; 5. MMSE score> 23 points; 6. Operation time>3h; 7. Sign the informed consent form and voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: 1. Age> 85 years; 2. Neurosurgery and cardiac surgery; 3. Patients with a history of neurological diseases, stroke, other significant central nervous system diseases or severe psychiatric diseases, multiple trauma and head trauma, endocrine or metabolic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The score was higher than that of the control group;Blood pressure was stable with little fluctuation;The score was higher than that of the control group;Short time to use;Differences were observed for multiple metabolites;Small changes in heart rate;Short time to use;The incidence of postoperative cognitive dysfunction is low; | — |
Secondary
| Measure | Time frame |
|---|---|
| No shivering;The patient was awake and quietly cooperative;Don't cough;VAS score for analgesia; | — |
Countries
China
Contacts
Public ContactXue Li
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed