Chronic hepatitis B
Conditions
Interventions
Clinical cure group obtained from NAs treatment:None
Clinical cure group achieved by combining NAs with Peg-IFNa therapy:None
Hepatitis B spontaneous clearance group:None
Treatment with nucleoside analogues without clinical cure group:None
Combining NAs with Peg-IFNa therapy without clinical cure group:None
Untreated without clinical cure group:None
Sponsors
Department of Infectious Diseases, Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients with previously diagnosed chronic hepatitis B who have achieved clinical cure without drug treatment or after NAs/Peg-IFNa treatment. Patients diagnosed with chronic type B and treated with NAs for more than 48 weeks, and the treatment duration is less than half a year different from that of the clinically cured patients, but no clinical cure has been obtained. Clinical cure requires four requirements: (1) HBsAg persistently undetectable, HBeAg negative transfection, with or without HBsAb; (2) HBV DNA below the lower limit of detection; (3) Liver function remained normal; (4) There were no other lesions in liver histology detected by other methods such as ultrasound. The diagnostic criteria refer to the Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2022 Edition)
Exclusion criteria
Exclusion criteria: (1) Combined with other hepatitis virus infections; (2) Combined with drug-induced liver injury, alcoholic liver disease, non-alcoholic fatty liver disease, autoimmune liver disease, etc.; (3) Combined with immunodeficiency diseases such as HIV; (4) Patients with malignant tumors of the liver or other sites; (5) Pregnant or lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| peripheral blood mononuclear cell ; | — |
Countries
China
Contacts
Public ContactZhang Dazhi
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed