Multiple Sclerosis
Conditions
Interventions
Experimental group:None
Control group:None
Sponsors
Xianyang Hospital of Yan'an University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with multiple sclerosis (MS): Meet international MS diagnostic criteria (e.g., McDonald criteria); Recruit patients with relapsing-remitting MS (RRMS); Regardless of whether they are receiving disease-modifying therapies (DMTs). (2) Healthy control group (Household Healthy Controls, HHCs): Healthy individuals living with MS patients (e.g., spouses or roommates); No MS or other autoimmune diseases; Have lived with MS patients for at least 6 months. (3) Other requirements: Aged 18 years or older; No severe comorbidities (e.g., cancer, severe cardiovascular diseases, etc.); Willing to provide stool and blood samples and complete relevant questionnaires.
Exclusion criteria
Exclusion criteria: (1) Common Exclusion Criteria for MS Patients and Healthy Controls: Use of oral antibiotics within the past 3 months; Use of corticosteroids within the past 30 days; Diagnosis of other autoimmune diseases (e.g., rheumatoid arthritis, inflammatory bowel disease); Diagnosis of other neurological diseases (e.g., Parkinson's disease, Alzheimer's disease); Severe psychiatric or psychological disorders that may affect questionnaire completion. (2) MS-Specific Exclusion Criteria: MS disease duration of less than 3 months. (3) Healthy Control-Specific Exclusion Criteria: No shared living environment with MS patients (e.g., not co-residing family members); Family history of MS or other neurological diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut Microbiome; | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-Hydroxytryptamine(5-HT); | — |
Countries
China
Contacts
Public ContactGuoxun Zhang
Xianyang Hospital of Yan'an University
Outcome results
None listed