Ovarian failure
Conditions
Interventions
Treatment group:In-situ injection of SVF into the ovary
Sponsors
The First Affiliated Hospital of Xiamen University
Eligibility
Sex/Gender
Female
Age
16 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1.Female subjects aged between 16 and 55 years old. 2.The duration of amenorrhea is more than six months and less than two years. 3.With an interval of more than 4 weeks, the follicle-stimulating hormone (FSH) level is greater than 40 U/L for two consecutive times. 4.The average diameter of each ovary was > 10mm; 5.Agreed to sign an informed consent form;
Exclusion criteria
Exclusion criteria: 1.Subjects tested positive for either treponema pallidum, HIV, hepatitis B virus or hepatitis C virus; 2.Abnormal blood clotting function, can not receive liposuction surgery or ovarian injection in situ; 3.Subjects with allergic predisposition; 4.Liver, heart, kidney and other important organs are not fully functional; (According to the diagnostic criteria of the tenth edition of Internal Medicine, the cardiac function rating (NYHA rating) is greater than or equal to grade II. The staging of renal function based on glomerular filtration rate and serum creatinine level is greater than or equal to the second stage. Liver function ALT, AST and bilirubin are more than or equal to 2 times the upper limit of standard value. 5.History of malignant tumors; 6.Treatment with growth hormone and/or estrogen-progestin for three months prior to treatment; 7.Participate in other clinical studies within three months prior to treatment; 8.There are autoimmune diseases or other serious medical and surgical diseases; 9.Abnormal chromosome karyotype; 10.Family history of severe genetic disorders; 11.Inability to follow up on treatment, follow-up, or refusal to participate in post-operative interviews; 12.Patients deemed ineligible for inclusion by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LH,E2,FSH,P,T,PRL;Hemodynamic indicators within the ovary;ATM;The restoration of menstruation; | — |
Countries
China
Contacts
Public ContactQionghua Chen
The First Affiliated Hospital of Xiamen University
Outcome results
None listed