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Study on the Mechanism by Which YBX1 Influences the Activation of Myofibroblasts and Collagen Deposition in Oral Submucous Fibrosis through the MUC1/ß-Catenin Axis

Study on the Mechanism by Which YBX1 Influences the Activation of Myofibroblasts and Collagen Deposition in Oral Submucous Fibrosis through the MUC1/ß-Catenin Axis - Study on the Mechanism by Which YBX1 Influences Oral Submucosal Fibrosis through the MUC1/ß-Catenin Axis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500100892
Enrollment
Unknown
Registered
2025-04-16
Start date
2025-05-01
Completion date
Unknown
Last updated
2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral submucosal fibrosis

Interventions

OSF group:OSF patient
Control group:Healthy oral mucosa tissue

Sponsors

The First Affiliated Hospital of Hainan Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: The oral mucosal lesion tissues of 20 OSF patients all had a history of chewing betel nuts, no special treatment and no other systemic diseases.

Exclusion criteria

Exclusion criteria: Twenty normal oral mucosa samples (normal control group) were obtained from patients who underwent tooth extraction due to orthodontic treatment or impacted wisdom teeth. None of them had oral mucosal disorders, and they had no bad habits such as chewing betel nuts, smoking or drinking alcohol. The oral mucosal tissues were taken from the gingiva or mucosal tissues adjacent to the extracted teeth.

Design outcomes

Primary

MeasureTime frame
Muscle fibroblast marker a-SMA;—

Countries

China

Contacts

Public ContactLuo Wen

The First Affiliated Hospital of Hainan Medical University

luowen228@163.com+86 151 0366 0395

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026