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Detection of nasopharyngeal carcinoma based on qPCR of VILL gene methylation in plasma cfDNA

Detection of nasopharyngeal carcinoma based on qPCR of VILL gene methylation in plasma cfDNA

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500100867
Enrollment
Unknown
Registered
2025-04-16
Start date
2024-10-18
Completion date
Unknown
Last updated
2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nasopharyngeal Carcinoma

Interventions

Gold Standard:Pathological diagnosis with biopsy histological specimen
Index test:methylation specific qPCR

Sponsors

General Hospital of Southern Theatre Command of PLA
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age must be at least 18 years old, with no gender restrictions; 2. Able to provide a venous blood sample of at least 5 mL or nasopharyngeal biopsy tissue; 3. Sign an informed consent form; 4. Participants suspected of having primary nasopharyngeal cancer. The inclusion criteria for the healthy control group were: normal blood routine, electrocardiogram, chest X-ray, abdominal ultrasound, and tumor marker test results.

Exclusion criteria

Exclusion criteria: 1. Have any systemic disease, such as diabetes, abnormal liver function, autoimmune disease, hematologic disease or other malignant tumors; 2. The patient has a history of radiotherapy, chemotherapy or immunotherapy; 3. Unable to sample or unqualified samples; 4. Failure to sign the informed consent document; 5. Subjects who are considered by the investigator to be inappropriate to continue to participate in this clinical trial.

Design outcomes

Primary

MeasureTime frame
Sensitivity;Specificity;Area Under The Curve;

Countries

China

Contacts

Public ContactYingjuan Wen

General Hospital of Southern Theatre Command of PLA

272878758@qq.com+86 135 1273 1756

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026