Hip Fracture
Conditions
Interventions
Tizanidine + celecoxib group:Oral tizanidine 6 mg 1 hour preoperatively and orally for 7 consecutive days (celecoxib 200 mg twice daily
oral tizanidine 4 mg three times daily).
Celecoxib group:Oral (6 mg placebo) 1 hour preoperatively and orally for 7 consecutive days (celecoxib 200 mg twice daily
oral placebo 4 mg three times daily)
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The diagnostic criteria are consistent with "Practical Orthopedics"; 2. Meet the relevant indications for surgery and anesthesia; 3. American Society of Anesthesiologists (ASA) anesthesia classification is grade II.~III.; 4. Age>=65 years; 5. First unilateral hip fracture with fresh closed fracture; 6. Received intramedullary nail or hollow screw and FNS treatment of proximal femoral anti-rotation screw; 7. Patients who are willing to participate and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Multiple fractures or open fractures, non-osteoporotic pathological fractures; 2. Patients with severe heart, lung and other vital organ diseases; 3. Those who are inactive or bedridden for a long time before injury or have neurological deficits, primary pain-causing diseases or pain intolerance; 4. Those with severe Alzheimer's disease or mental illness or who are unable to cooperate or do not cooperate; 5. History of active peptic ulcer or bleeding within 6 months; 6. Those who take relevant analgesic drugs or are allergic to non-steroidal anti-inflammatory drugs (NSAIDs) or are dependent on analgesic and anesthetic drugs before admission; 7. Those who are allergic to drugs related to this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative diazoxide consumption;Postoperative tramadol consumption;Pain scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality;Transferase level (enzyme);Time to first analgesic resuscitation;Length of postoperative hospitalization; | — |
Countries
China
Contacts
Public ContactLuo Yue
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed