Application of liposomal bupivacaine in anterior sciatic nerve combined with saphenous nerve block for postoperative analgesia in below-the-knee orthopedic surgery

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500100843

Enrollment

Unknown

Registered

2025-04-16

Start date

2025-04-16

Completion date

Unknown

Last updated

2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

below-the-knee orthopedic surgery

Interventions

LB group:Liposomal Bupivacaine

BD group:Bupivacaine and dexameshasone

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 80 years 2. Body mass index was 15~30 kg/m^2 3. The American Society of Anesthesiologists (ASA) classification is I ~ III level

Exclusion criteria

Exclusion criteria: 1. Severe heart and lung disease 2. Chronic pain treatment or chronic steroid therapy 3. Mental illness 4. Allergy to the study drugs

Design outcomes

Primary

Measure	Time frame
AUC of pain NRS at rest from 6 to 72h postoperatively;	—

Secondary

Measure	Time frame
AUC of pain NRS during movement from 6 to 72 h postoperatively;NRS scores at different time after surgery;Oxycodone consumption in different time periods during 72 h postoperatively;The duration of analgesia;	—

Countries

China

Contacts

Public ContactQing-Ren Liu

Xishan People’s Hospital of Wuxi City

liuqr5250@163.com+86 136 0151 0512

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026