lactose intolerant in Infants
Conditions
Interventions
Control group:none
Lactose intolerance group:None
Placebo group:Lactose intolerance + lactase + placebo
Probiotic group:Lactose intolerance + lactase + probiotic
Sponsors
Jingdezhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1. Infants 0 to 12 months old who meet the standard diagnosis of lactose intolerance have normal weight and height. Diagnostic criteria for neonatal lactose intolerance: (1) Related symptoms, including abdominal distension, increased frequency of defecation, and increased frequency of milk vomiting. (2) Laboratory indicators: fecal reducing sugar >= 0.25% or fecal pH <=5.5. 2. The patients are generally in good condition and have no other serious heart, lung, kidney, liver dysfunction and metabolic diseases. 3. No antibiotics or other drugs or probiotics were used in the first 3 months after the completion of treatment.
Exclusion criteria
Exclusion criteria: 1. Patients who did not meet the inclusion criteria. 2. Have a severe active viral or bacterial infection that is not controlled by treatment. 3. A history of birth asphyxia (1-minute Apgar score < 7). 4. There are serious congenital malformations, such as digestive tract malformations, congenital heart disease, etc. 5. Peripheral blood eosinophilia is considered to be milk protein allergy. 6. Suspected or confirmed neonatal necrotizing enterocolitis (NEC) . 7. There are serious infections, elevated hemolytic liver enzymes, thrombocytopenia (HELLP) syndrome, tumors and other diseases in the mother's pregnancy. 8. Have any other serious or chronic medical condition that the investigators believe may affect the treatment, follow-up, or evaluation of the child. It includes any uncontrolled and clinically significant neurological, psychiatric, immune-regulatory, metabolic and infectious diseases. 9. Children who are not suitable for probiotic adjuvant therapy after diagnosis and evaluation by clinicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical function;immunoglobulin;Composition of gut microbiota; | — |
Countries
China
Contacts
Public ContactXuewei Lei
Jingdezhen Second People's Hospital
Outcome results
None listed