Intracranial major artery occlusion
Conditions
Interventions
Indirect revascularization surgery combined with standard medical treatment group/standard medical treatment alone group:None
Sponsors
The first medical center of Chinese PLA general hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18-65 years old; 2. Intracranial aortic occlusion diagnosed by CTA or MRA, and the vascular lesion has been stable on imaging for more than 1 month; 3. Have had the onset of ischemic symptoms related to the diseased blood vessel or the stenosis of the diseased blood vessel in the past 90 days> 90%; 4. No cerebellar artery involvement, and poor collateral circulation (ASTIN score <3 or CCG collateral circulation score <8 points); 5. Improved Rankin score 0-2; 6. No previous intracranial hemorrhage, and more than 4 weeks since the latest stroke onset; 7. CT or MRI scan did not show a large area (more than 50% of the blood supply area of a single vessel or 50% of the total volume of the cerebral hemisphere); 8. Agree to sign the informed consent form and be able to cooperate with the follow-up visit
Exclusion criteria
Exclusion criteria: 1. Patients with other cerebrovascular diseases, such as intracranial aneurysm, cerebral arteriovenous malformation, etc.; 2. Patients who have previously undergone intracranial and extracranial revascularization surgery or endovascular therapy; 3. Patients with a history of malignant tumors, myocardial infarction or other serious underlying diseases, with a risk of sudden death or a life expectancy of 3mg/dL or eGFR <30 cc/min), coagulation insufficiency (platelet count < 10 000/ml), heart failure (ejection fraction <25%) or other patients who cannot tolerate surgery and anesthesia; 7. Patients who are allergic to or cannot tolerate basic treatment drugs such as aspirin; 8. Patients with severe trauma, stress, infection or major surgery in the past 1 month; 9. Pregnant or lactating women; 10. Patients who have participated in other clinical trials and may affect the results of this study; 11. Patients with dementia, severe mental illness or unable to cooperate with cognitive function assessment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Any Stroke events and all cause mortality;Ischemic stroke events for lesion artery territory ; | — |
Secondary
| Measure | Time frame |
|---|---|
| All fatal or disabling stroke events (e.g., cerebral infarction, intracranial hemorrhage, recurrent transient ischemic attacks) involving bilateral cerebral hemispheres;All cause mortality;mRS scale;Cognition function evaluation;Imaging evaluation of Revascularization (Matsushima grade based on DSA);Perfusion CBF improvement; | — |
Countries
China
Contacts
Public ContactCong Han
The first medical center of Chinese PLA general hospital
Outcome results
None listed