None
Conditions
Interventions
Experimental Group(PCIA-LB):1. In the abdominal closure stage, after the suturing of the rectus fascia layer, two fixed surgeons will administer bupivacaine liposomal local infiltration block above th
PCA dose: 2-3ml
The interval time is 15-20min
Control Group(PCIA-NS):1. In the abdominal closure stage, after the suturing of the rectus fascia layer, two fixed surgeons will give local infiltration block above and subcutaneously above the rectus
Sponsors
Beijing Tsinghua Changgung Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18~65 years old; 2. Patients who intend to undergo elective CRS-HIPEC surgery 3. Body mass index (BMI): 18~28 kg/m^2; 4. American Society of Anesthesiologists (ASA) grade I.~III.; 5. Postoperative signing of opioid analgesic pumps.
Exclusion criteria
Exclusion criteria: 1. Severe hepatic and renal dysfunction (defined as glomerular filtration rate =1.5); 4. Refusal to participate in this study; 5. History of alcohol or drug abuse; Suffering from mental illness and impaired mental status. 6. Chronic opioid users (more than 3 months of use); Presence of chronic pain (pain lasting more than 3 months)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative three-day NRS movement pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative three-day NRS resting pain score;Morphine equivalent consumption;Effective presses of the analgesic pump;Quality of early postoperative recovery (QoR-15);Number of rescue analgesia administrations within 72 hours postoperatively;Patient satisfaction with analgesia; Adverse reactions during analgesic therapy (respiratory depression, dizziness, nausea and vomiting, pruritus, urinary retention, etc.;Postoperative adverse events; | — |
Countries
China
Contacts
Public ContactZhang Huan
Beijing Tsinghua Changgung Hospital
Outcome results
None listed