Stroke
Conditions
Interventions
Experimental group 1:conventional training and left DLPFC-repeated Transcranial magnetic stimulation
Experimental group 2:conventional training and affected side-repeated Transcranial magnetic stimulation
Control group:conventional training and left DLPFC-rTMS sham stimulation
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for stroke adopted by the Fourth National Conference on Cerebrovascular Disease and confirmed by cranial CT or MRI, including cerebral infarction, cerebral haemorrhage and cerebral embolism; (2) Aged 18-75 years old, with the first onset of the disease and the duration of the disease within 6 months; (3) Stable vital signs, mRS = 4) on a standardised fatigue rating scale before rTMS treatment; (5) Patients and their families were informed about the study and agreed to participate.
Exclusion criteria
Exclusion criteria: (1) Severe dementia or impaired consciousness, inability to complete scale-related examinations: GCS score <15, MoCA score <19, or cognitive dysfunction as assessed by the MMSE (illiterate <17, primary school group <20, junior high school and above <24); (2) Concomitant with stroke other neurological related diseases or psychiatric related serious diseases (including schizophrenia, severe cognitive impairment, multiple sclerosis, Parkinson's syndrome, traumatic brain injury, epilepsy, cerebral oedema, etc.); (3) Drug use: use of centrally acting drugs that may affect levels of fatigue, depression and anxiety, such as rifampicin, fluoxetine, paroxetine, sertraline, citalopram, fluvoxamine benzodiazepines, hormones and other drugs; (4) Other medical conditions: patients with previous known high prevalence of fatigue, such as tumours, or a combination of other medical conditions or serious illnesses that may interfere with the assessment of fatigue, such as sleep apnoea, episodic somnambulism, hypothyroidism, heart failure, chronic obstructive pulmonary disease; (5) Those with unstable medical conditions and a tendency to deteriorate; (6) Pregnant and lactating women; (7) Contraindications to MRI (e.g. metal foreign bodies in the body) or claustrophobia; (8) Participants who are unwilling or unable to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale, VAS-f;Fatigue Severity Scale, FSS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain activation;Emotion;Motor evoked potential;Sleeping;Activities of daily living;Heart rate variation;quality of life; | — |
Countries
China
Contacts
Public ContactYangyun Xuguangxu
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed