Repeated Pulmonary Infection and Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Children with recurrent pulmonary infection group:None
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 1-18 years, gender is not limited; 2. Children with pneumonia before the age of 2 years; 3. Meet the diagnostic criteria for recurrent lower respiratory tract infections in children; 4. Meet the diagnostic criteria for severe pneumonia in children; 5. Voluntary test, informed consent of the child and legal guardian and signing of the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Exclude other diseases that cause cough and wheezing, such as primary ciliary dyskinesia and congenital bronchopulmonia Children with dysplasia, foreign body aspiration, tuberculosis, cystic fibrosis, etc., and children after cord blood stem cell transplantation; 2. Children with coagulation function and platelet count before bronchoalveolar lavage, and potential bleeding risk; 3. Combined with severe primary diseases such as cardiovascular and cerebrovascular, liver, kidney, hematopoietic system and endocrine system Serious illness that is considered inappropriate to participate in this study; 4. Indications for invasive mechanical ventilation and non-invasive ventilator application; 5. Participated in or is participating in other clinical trials in the past 1 month; 6. The investigator believes that it is not suitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA methylation analysis of BALF samples;The DNA methylated CpG of COPD was established through GEO database, and the association between it and repeated lung infections in children was analyzed.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline clinical data of children;Follow-up of pulmonary function and pulmonary CT after discharge; | — |
Countries
China
Contacts
Public ContactJianning Guo
China-Japan Friendship Hospital
Outcome results
None listed