Knee osteoarthritis
Conditions
Interventions
Healthy control group:None
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with knee OA: 1) Age 50-70 years; 2) Diagnosis of primary severe OA according to the American College of Rheumatology Knee Osteoarthritis OA diagnostic criteria and K-L grade 3-4; 3) chronic pain with onset of pain >=1 year and duration >=3 months; 4) Voluntarily participate in the study and sign the informed consent form. Volunteer: 1) Age 50-70 years; 2) American College of Rheumatology diagnostic criteria and imaging confirmed not to meet the OA manifestations of knee osteoarthritis; 3) No history of knee surgery and treatment; 4) no neurological disease; 5) no history of severe head trauma; 6) No history of mental illness; 7) No cognitive dysfunction (MMSE score and MoCA score= the cut-off value corresponding to the corresponding academic qualifications); 8) Voluntarily participate in the study and sign the informed consent form; 9) No implants in the body, non-claustrophobic patients.
Exclusion criteria
Exclusion criteria: Patients with knee OA: 1. Non-degenerative knee osteoarthritis OA caused by trauma, iatrogenic and rheumatoid disease; 2. Any other disease that causes chronic pain or mood changes; 3. Suffering from neurological diseases; 4. History of severe head trauma; 5. History of psychiatric illness; 6. Cognitive dysfunction (MMSE and MoCA scores); 7. In vivo implants, claustrophobic patients. Volunteer: Volunteers who do not meet the criteria for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortical gray matter volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| Amplitude of low-frequency fluctuation;Regional homogeneity;Seed-based functional connectivity;Fractional ALFF; | — |
Countries
China
Contacts
Public ContactGuo Lin
The First Affiliated Hospital of Army Medical University
Outcome results
None listed