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Effect of articaine hydrochloride and epinephrine tartrate injection assisted anesthesia on pain and swelling following mandibular impacted third molar extraction

Effect of articaine hydrochloride and epinephrine tartrate injection assisted anesthesia on pain and swelling following mandibular impacted third molar extraction

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500100753
Enrollment
Unknown
Registered
2025-04-15
Start date
2025-04-20
Completion date
Unknown
Last updated
2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mandibular impacted third molar

Interventions

The preoperative inject articaine hydrochloride and epinephrine tartrate injection group:The surgery was performed after lidocaine block anesthesia and local infiltration anesthesia with articaine hyd
The postoperative inject articaine hydrochloride and epinephrine tartrate injection group:Lidocaine block anesthesia after surgery, followed immediately by the addition of articaine hydrochloride and
The blank control group:The surgery was performed after routine lidocaine block anesthesia.

Sponsors

Affiliated Stomatological Hospital of Nanjing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18–45 years old, gender unlimited. 2. Mandibular third molar teeth affected need to be removed. 3. There was no inflammation, infection, or pain at the surgical site 7 days before surgery. 4. Can cooperate with the test and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. The affected tooth is in the acute inflammatory stage. 2. Patients with uncontrolled systemic diseases, such as diabetes and heart disease. 3. There are benign or malignant tumors in the mouth or jaw. 4. Mental abnormality without normal behavioral capacity. 5. Allergy to local anesthetic drugs. 6. Currently participating in other clinical trials. 7. Periodontitis, caries, or periapical periodontitis in the adjacent teeth. 8. Have taken painkillers, anti-inflammatory drugs, antidepressants, corticosteroids, or other medications within the past week. 9. Postoperative infection.

Design outcomes

Primary

MeasureTime frame
Pain level;Swelling score;

Secondary

MeasureTime frame
Number of painkillers taken;Satisfaction score;

Countries

China

Contacts

Public ContactFu Yu

Affiliated Stomatological Hospital of Nanjing Medical University

2935843647@qq.com+86 178 6048 8621

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026