Growth hormone deficiency, GHD
Conditions
Interventions
Observation group:None
Group treated with rhGH:None
Sponsors
Children's Hospital of Soochow University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Clinically diagnosed as intracranial tumor; 2.Tumor resection and/or chemoradiotherapy was performed; 3.Patients with postoperative GHD should receive growth hormone supplementation based on clinical and laboratory results(Consensus recommends:Children with clinical growth retardation, sellar lesions, and >= 1 other pituitary hormone deficiency can be diagnosed as GHD based on the fact that IGF-1 is lower than the normal range corresponding to the same gender, without GH provocation test. When the level of IGF-1 is within the normal range, GH stimulation test should be performed to recognize GHD); 4.If there are multiple hormone deficiencies, corticosteroid and thyroid hormone deficiencies should be corrected in turn before growth hormone replacement therapy. 5.No previous use of growth hormone;
Exclusion criteria
Exclusion criteria: 1.Epiphyseal closure; 2.Patients with underlying tumor recurrence showing any signs of progression; 3.Previous use of height-improving drugs (including growth hormone, IGF-1 supplements, and growth hormone receptor agonists); 4.Allergic to growth hormone; 5.Any other condition that the investigator considers inappropriate for inclusion in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Annual growth rate(HV); | — |
Secondary
| Measure | Time frame |
|---|---|
| Ratio of the subjects' HV faster than 6cm/year, ?Ht-SDS, ?IGF-1 SDS;Comprehensive outcome : score of life quality;Safty: AE and SAE; | — |
Countries
China
Contacts
Public ContactXie Rongrong
Children's Hospital of Soochow University
Outcome results
None listed