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Application of esketamine in analgesia after hip arthroplasty in elderly orthopedic patients

Application of esketamine in analgesia after hip arthroplasty in elderly orthopedic patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500100721
Enrollment
Unknown
Registered
2025-04-14
Start date
2021-08-15
Completion date
Unknown
Last updated
2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after hip replacement

Interventions

GroupA:The analgesic pump formula was sufentanil 2ug / kg + tropisetron 10mg, background infusion flow rate 2ml/h, single additional dose 2ml, locking
GroupB:The analgesic pump formula was sufentanil 1.5ug / kg + tropisetron 10mg, background infusion flow rate 2ml/h, single additional dose 2ml, locking
GroupC:he analgesic pump formula was sufentanil 1 ug/ kg + tropisetron 10mg, background infusion flow rate 2ml/h, single additional dose 2ml, locking

Sponsors

People's Hospital of Deyang City
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Age 60-90 years old; 2. Both male and female; 3. Per capita of all races; 4. Patients need postoperative analgesia PCIA; 5. Patients need postoperative analgesia PCIA; 6. The patient signed the written consent form for anesthesia and postoperative analgesia.

Exclusion criteria

Exclusion criteria: 1. Patients have serious underlying diseases, such as poorly controlled hypertension, severe ischemic heart disease, congestive heart failure and poor liver and kidney function, kidney disease requiring dialysis, etc. 2.The patient refused postoperative analgesia and did not sign the consent form for postoperative analgesia; 3. Those who are allergic to esmolamine or excipients; 4. Patients with severe risk of elevated blood pressure or intracranial pressure; 5. Patients with severe mental disorders; 6. Patients with hyperthyroidism without treatment or ineffective treatment; 7. Patients with high intraocular pressure, such as glaucoma. Patients with drug abuse or dependence. 8. Patients with drug abuse or dependence.

Design outcomes

Primary

MeasureTime frame
Visual analogue scale (VAS);

Secondary

MeasureTime frame
Ramsay sedation score (RSS);Adverse reaction;Proportion of patients in need of rescue and analgesia;QOR15 score 48 hours after operation;First walking time;

Countries

China

Contacts

Public ContactJia Han

People's Hospital of Deyang City

453922152@qq.com+86 838 2418184

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026