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The role and mechanism of deoxycholic acid in pulmonary hypertension and pulmonary vascular remodeling

The role and mechanism of deoxycholic acid in pulmonary hypertension and pulmonary vascular remodeling

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500100718
Enrollment
Unknown
Registered
2025-04-14
Start date
2023-09-11
Completion date
Unknown
Last updated
2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary arterial hypertension

Interventions

Observation group:None

Sponsors

The second affiliated hospital of Harbin Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age 18~75 years old, hemodynamic examination by right heart catheterization in accordance with the 2022 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension (pulmonary artery mean pressure>20mmHg, pulmonary arteriolar wedge pressure 3WU); 2. Patients with PAH without any treatment; 3. And obtain the patient's informed consent.

Exclusion criteria

Exclusion criteria: 1. The data is incomplete or cannot be analyzed; 2. Other types of PH, including left heart system disease, respiratory disease or hypoxia, PH caused by pulmonary artery obstruction, PH caused by multiple factors, etc.; 3. Patients who cannot tolerate right heart catheterization or refusal; 4. Severe renal insufficiency; 5. Acute or chronic infection; 6. Combined with digestive tract diseases, such as digestive tract tumors, inflammatory bowel disease, irritable bowel syndrome and gastroenteritis.

Design outcomes

Primary

MeasureTime frame
All-cause mortality;

Secondary

MeasureTime frame
Clinical deterioration;

Countries

China

Contacts

Public ContactBingxiang Wu

The second affiliated hospital of Harbin Medical University

wubingxiang1964@163.com+86 186 4517 3737

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026