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Study on the discovery of biomarkers of early renal injury in obstructive nephropathy

Study on the discovery of biomarkers of early renal injury in obstructive nephropathy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500100714
Enrollment
Unknown
Registered
2025-04-14
Start date
2025-05-31
Completion date
Unknown
Last updated
2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive nephropathy

Interventions

Experimental group 1 ( patients with obstructive urine ):None
Control group 1 ( healthy people, obtain healthy people 's urine ):None
Experimental group 2 ( kidney tissue removed due to loss of function of hydronephrosis ):None
Control group 2 ( adjacent normal kidney tissue obtained from tumor resection ):None

Sponsors

Zhongnan Hospital of Wuhan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Age 16-80 years old, gender unlimited ; 2.Patients with obstructive nephropathy diagnosed by anterograde and / or retrograde urography, CT urography ( CTU ), renal dynamic imaging and other imaging examinations ( experimental group 1 ) ; healthy people with no obstructive nephropathy proved by physical examination ( control group 1 ) ; patients who lost function due to obstruction and underwent surgical resection of the affected kidney ( experimental group 2 ) ; patients whose kidneys were removed due to tumors and normal renal tissues adjacent to the cancer could be obtained ( control group 2 ) ; 3.Signed informed consent, volunteered to participate in the study, and willing to cooperate with follow-up and data collection.

Exclusion criteria

Exclusion criteria: 1. A history of recurrent pyelonephritis, cystitis glandularis and other urinary tract infections ; 2.Patients with other types of kidney disease ; 3.Patients younger than 18 years old ; 4.Long-term oral immunosuppressive agents after organ transplantation.

Design outcomes

Primary

MeasureTime frame
Urography;

Secondary

MeasureTime frame
Ultrasonography;Radionuclide renal dynamic imaging;Spiral CT urography;Renal pelvis pressure;

Countries

China

Contacts

Public ContactBing Li

Zhongnan Hospital of Wuhan University

bingli2023@whu.edu.cn+86 138 7136 1899

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026