Evaluation of the efficacy of Lactobacillus crispatus in improving postoperative symptoms in patients with endometrial polyps

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500100710

Enrollment

Unknown

Registered

2025-04-14

Start date

2024-01-10

Completion date

Unknown

Last updated

2025-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

endometrial polyps

Interventions

Control group(A Group):No intervention

Progesterone treatment group (P group):Oral progestins

Probiotics group (I group):Vaginal Probiotics+Oral progestins

Eligibility

Sex/Gender

Female

Age

20 Years to 55 Years

Inclusion criteria

Inclusion criteria: (1) Control group (group A) inclusion criteria: A. Women of childbearing age (20-55 years old) with regular menstrual cycle; b. no sexual activity within 7 days before the examination; c. Vaginal discharge, cervical cancer screening and gynecological color Doppler ultrasound examination showed no obvious abnormalities; (2) Surgery group (group P / I) inclusion criteria: a. women of childbearing age (20-55 years old); b. Endometrial polyps confirmed by hysteroscopy and postoperative pathology; c. no sexual activity within 1 week before the examination; d. No history of allergy to probiotics.

Exclusion criteria

Exclusion criteria: a. asexual life history; b. The patient is in the menstrual period, pregnancy, lactation and menopause; c. Combined with severe heart, lung, liver, kidney dysfunction, malignant tumor and metabolic immune-related diseases; d. systemic use of antibiotics or vaginal irrigation in the past 1 month; e. use of other estrogen-progestin containing or estrogen-progestin interfering drugs within the past 1 month; f. participating in clinical intervention studies of other investigational drugs or devices during the same period; g. Preparation for pregnancy during the planned period of the study.

Design outcomes

Primary

Measure	Time frame
Analysis of vaginal microbiota;Routine examination of vaginal secretions;Blood routine examination;Questionnaire;	—

Secondary

Measure	Time frame
Endometrial polyp recurrence rate;VAS Pain Assessment Scale;Incidence of Abnormal uterine bleeding;Incidence of discomfort in the external genitalia;Patient's subjective feelings;	—

Countries

China

Contacts

Public ContactQi Chen

the Second Affiliated Hospital of Nanchang University

chenqiyangbai@126.com+86 138 0791 2933

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026