High-Functioning Autism Spectrum Disorder
Conditions
Interventions
Healthy control:No treatment
Sham control group:Sham coil treatment
Sponsors
The Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosed by two child psychiatrists as meeting the DSM-5 diagnostic criteria for autism spectrum disorder (ASD), with an intelligence quotient (IQ) >=70; 2.Aged 6-18 years, of Han ethnicity and right-handed; 3.No apparent contraindications to iTBS and willing to undergo iTBS treatment; 4.Normal findings on conventional brain MRI (including 3D BRAVO and T2-weighted imaging); 5.No contraindications for MRI scanning (e.g., claustrophobia, cardiac pacemaker implantation); 6.Head motion during fMRI scanning <2mm translation and <2° rotation;
Exclusion criteria
Exclusion criteria: 1.Evidence of organic diseases identified through physical examination or laboratory tests that could reasonably explain the severity, variability, or persistence of symptoms; 2.Presence of neurological or endocrine system disorders; 3.History of alcohol or substance abuse; 4.Previous treatment with iTBS or electroconvulsive therapy (ECT); 5.Comorbid psychiatric disorders (e.g., schizophrenia, bipolar disorder, depressive disorders), personality defects, or poor treatment adherence that may significantly affect therapeutic outcomes, behavioral assessments, or neuroimaging examinations; 6.Documented history of organic diseases (e.g., pulmonary diseases, cardiac diseases, diabetes mellitus, arthritis or osteoarthritis, rheumatic diseases, neoplasms, hypertension, gastrointestinal organic diseases, hepatic diseases, chronic fatigue syndrome, allergies, trauma, or other unspecified organic diseases).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emotion regulation ability; | — |
Secondary
| Measure | Time frame |
|---|---|
| Social functioning;Resting-State Functional Magnetic Resonance Imaging;Emotional state;Cognitive function; | — |
Countries
China
Contacts
Public ContactChen Lei
The Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed