Sleep disturbance
Conditions
Interventions
Contral Group:Opioid anesthesia group
Experimental group:Opioid-free anesthesia group
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: [1] Han Chinese [2] age between 18 and 60 years [3] American Society of Anesthesiologists (ASA) physical status I to III [4] Patients scheduled for elective thyroidectomy
Exclusion criteria
Exclusion criteria: [1] The patient refused to participate in the research. [2] Allergic to dexmedetomidine, lidocaine or esketamine [3] Long-term treatment with beta-blockers or HR <50 bpm [4] Left ventricular ejection fraction (LVEF) <40% [5] apnea-hypopnea index (AHI) = 5/h [6] periodic limb movements during sleep (PLMS) = 20/h [7] body mass index = 30 kg/m2 or < 18kg/m2 [8] Using sedative-type opioids or sleep-promoting drugs [9] Having mental or neurological disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sleep disturbance on the first postoperative day; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of sleep disturbance on postoperative day 3;Sleep quality at 1 month postoperatively;Sleep structure on the first night postoperatively;Patient's quality of recovery score on the first and third postoperative days;Anxiety and depression scores on the first, third, and 30th postoperative days;Rest and movement pain scores on postoperative day 1 , 3 and 30;The sleep quality scores on postoperative day 1 and 3 ;Postoperative adverse reactions;Perioperative hemodynamic changes; | — |
Countries
China
Contacts
Public ContactJianjun Yang
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed