Cerebral arteriovenous malformations
Conditions
Interventions
Transvenous interventional embolization treatment group:Transvenous embolization therapy
Sponsors
The First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital)
Eligibility
Sex/Gender
All
Age
13 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosis of BAVM: Diagnosis of BAVM is confirmed by MR/CTA/DSA. 2.Age= 13 years old = 60 years old; 3. single or two dominant venous drainage; 4.The diameter of the deformity during TVE< 3.5cm; 5.Obtain informed consent signed by the research participant or his/her legal guardian or representative.
Exclusion criteria
Exclusion criteria: 1.Pregnancy or lactation; Premenopausal female patients with positive urine or plasma pregnancy test (no documented history of surgical sterilization); 2.Patients with bilateral mydriasis at the time of admission; 3.Combined tumors, bleeding disorders or other known serious underlying diseases (such as chronic obstructive pulmonary disease, multi-organ insufficiency, severe diabetes, cardiac insufficiency and chronic kidney disease, etc.); 4.mRS = 3 points due to intracranial hemorrhage or neurological dysfunction before treatment 5.Radiological image confirmed with ruptured aneurysm; 6.The bAVM is too diffuse; 7.Platelet count 1.4, or elevated TP or ATPP; Patients requiring long-term anticoagulation; 9.Other conditions that are not suitable for enrollment (determined by two doctors); 10. Patients participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Good prognosis rate of neurological function after 180 days (6 months) of enrollment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immediate complete occlusion rate postoperatively;BAVM occlusion rate of cerebral angiography at 6 months after surgery;Stroke events within one week of enrollment to the end of embolization;Stroke events at clinical follow-up one week after embolization to 1 year; | — |
Countries
China
Contacts
Public ContactJianmin Liu
The First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital)
Outcome results
None listed