Postoperative Delirium
Conditions
Interventions
Normal saline group:Equal volume of saline infusion,continued until 15 minutes before the end of surgery
Dexmedetomidine group:A loading dose of dexmedetomidine 0.4 mg/kg is administered over 10 minutes, followed by a maintenance infusion of 0.2–0.4 µg/kg/h (concentration: 4 mg/mL), continued until 15 mi
Sponsors
Li Huili Hospital Affiliated to Ningbo University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: There were 96 senile and frail patients with complex shoulder arthroscopic surgery, regardless of gender, aged 65~85 years old, ASAI.~III. grade
Exclusion criteria
Exclusion criteria: (1) History of severe cardiovascular and cerebrovascular diseases such as cerebral infarction and myocardial infarction in the past six months; (2) history of previous dementia or psychiatric illness; (3) Patients who are unable to cooperate with the completion of the Mini-Mental State Examination (MMSE) or whose score is lower than the corresponding minimum score (illiterate <=17 points, primary school <=20 points, secondary school <=22 points, and university <=23 points); (4) Severe liver and kidney impairment; (5) Long-term alcoholics or psychotropic drug addicts; (6) Patients with moderate to severe anemia; (7) Severe visual or hearing impairment; (8) Patients with severe arrhythmia before surgery; (9) Refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regional cerebral oxygen saturation;Heart rate;Mean arterial pressure, MAP ;Sedation-agitation scale;Confusion assessment method; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia duration;Surgery duration;PACU stay duration;Simple mental intelligence scale score;Total amount of anesthetic drugs;Numerical rating scale; | — |
Countries
China
Contacts
Public ContactXianyu Wencui
Li Huili Hospital Affiliated to Ningbo University
Outcome results
None listed