severe pneumonia
Conditions
Interventions
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years old; 2.Voluntary signing of the informed consent form; 3.Patients who meet the diagnostic criteria for severe pneumonia within no more than 48 hours;
Exclusion criteria
Exclusion criteria: 1.Patients with severe pneumonia secondary to severe infection of other sites; 2.Fibrobronchoscopy could not be performed during enrollment or there were contraindications to fibrobronchoscopy, such as uncorrected bleeding tendencies or severe abnormalities in coagulation function; 3.Pregnant or lactating women; 4.Patients with malignant tumors whose end-stage life expectancy is less than 3 months; 5.Patients with chemoradiotherapy or immunodeficiency disease in the last 3 months; 6.If researchers judged that it was not suitable to participate in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| day-28 mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality during ICU stay;Cumulative incidence of mechanical ventilation (noninvasive ventilation, tracheal intubation) in patients with severe pneumonia;day-90 mortality;length of ICU stay;Days of mechanical ventilation in mechanically ventilated patients;Cumulative incidence of tracheal intubation among patients receiving noninvasive ventilation at baseline(Day0);Changes in SOFA scores at baseline (Day0) and day 7;Cumulative incidence of vasopressor therapy within 28 days in patients not receiving vasopressors at baseline(Day0);Changes in oxygenation index at baseline (Day0) and day 7; | — |
Countries
China
Contacts
Public ContactZheng Lei
Southern Medical University Southern Hospital
Outcome results
None listed