intra-abdominal infection caused by digestive tract perforation
Conditions
Interventions
High protein group:None. Protein intake >= 2.0g/kg/ day
Low protein group:None. Protein intake <2.0g/kg/ day
Sponsors
Liuzhou people's hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-80 years; 2.Newly admitted to ICU within 2 days with an anticipated ICU stay >= 2 days; 3.APACHE II score >= 15 or SOFA score >= 6; 4.Patients with intra-abdominal infections secondary to gastrointestinal perforation; 5.Patients receiving supplemental protein nutrition therapy; 6.Signed informed consent form by patients or legal guardians;
Exclusion criteria
Exclusion criteria: 1.Patients anticipated for discharge within 7 days; 2.Current serum creatinine level exceeds the upper limit of normal range; 3.Patients with severe acute kidney injury, severe hepatic disorders (e.g., hepatic encephalopathy), or severe metabolic diseases; 4.Lactating, pregnant, or renal transplant recipients; 5.Patients with intolerance to >= 1L fluid intake (e.g., severe heart failure); 6.Patients with malignant tumors; 7.Other conditions deemed ineligible by investigators;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma proteome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of ICU stay;Health-related Quality of Life Score (EQ-5D-5L);The rate of new infections occurred before ICU discharge or death;Indicators of organ dysfunction;Mortality rate during the period of hospitalization; | — |
Countries
China
Contacts
Public ContactMeiqiong-Liu
Liuzhou people's hospital
Outcome results
None listed