Parkinon's disease
Conditions
Interventions
Sham stimulation group:rTMS sham stimualtion
rTMS group:low frequency rTMS
cTBS group:continuous ? burst stimulation
Sponsors
the Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1 Age of presentation >=18 years old; 2 Han nationality; 3 Diagnosis of clinically confirmed Parkinson's disease according to the 2015 MDS PD diagnostic criteria; Patients who have received dopaminergic drug therapy for a course of >=30 days and maintain the original drug regimen during the treatment period; 4. Complete the signing of the informed consent form; 5 Pittsburgh sleep quality index (PSQI) score >5.
Exclusion criteria
Exclusion criteria: 1 Is using any type of sleep aid, sedative, antidepressant, or other psychoactive medication; 2. There are obvious stressful or stressful events recently, such as widowhood, death of a relative, unemployment, etc.; 3. Contraindications to transcranial magnetic stimulation, including previous severe head trauma or cerebral surgical intervention, history of epilepsy, active tumor, intracranial hypertension, ferromagnetic device implantation such as pacemaker, neurostimulator, etc.; 4 History of receiving any form of transcranial magnetic stimulation or transcranial electrical stimulation in the past 3 months; 5 Cognitive impairment (MMSE scale <22 points); 6. Unable to continue to cooperate with the study due to illness or personal reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical sleep parameter;Subjective sleep parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| EEG;Motor symptom; | — |
Countries
China
Contacts
Public ContactZhuang Sheng
The Second Affiliated Hospital of Soochow University
Outcome results
None listed