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Construction of a Precision Diagnostic Model Integrating Disease and Syndrome for Dampness-Heat Gout

Effective constituents and mechanism of Ermiao San series of formula for treating damp-heat gout based on integrating the big data of in vivo compounds targets-pathways originated from clinical and animal model—Construction of a Precision Diagnostic Model Integrating Disease and Syndrome for Dampness-Heat Gout.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500100614
Enrollment
Unknown
Registered
2025-04-11
Start date
2025-04-20
Completion date
Unknown
Last updated
2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Damp-heat type gout

Interventions

Gout patients:None

Sponsors

Guangdong Provincial Hospital of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Healthy population (1) Aged between 18 and 60 years old; (2) A state of complete body structure and good function, without any diseases or disabilities; (3) The physical condition is peaceful; (4) The participant agrees to participate in this study and signs an informed consent form. 2. Gout patients (1) The research subjects meet the 2015 ACR/EULAR diagnostic criteria for gouty arthritis; (2) Aged between 18 and 60 years old; (3) Irregular treatment in the past 2 weeks; (4) The participant agrees to participate in this study and signs an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Healthy population (1) Pregnant or lactating women; (2) People who have taken any health supplements or regular supplements in the past two weeks; (3) Individuals with liver function, kidney function, blood lipids, blood glucose, blood uric acid, blood routine, and urine routine exceeding 1.5 times normal values. 2. Gout patients (1) Patients with severe cardiovascular, brain, lung, liver, kidney, hematopoietic system diseases, malignant tumors, and mental illnesses; (2) Pregnant or lactating women; (3) Patients with secondary gout caused by underlying diseases or the use of medications such as aspirin, cyclosporine, diuretics, etc.

Design outcomes

Primary

MeasureTime frame
Metabolomics assays;Whole genome sequencing of intestinal flora;Inflammatory indicators (ESR, CRP);Traditional Chinese Medicine Gout Syndrome Diagnosis Form;Gout Syndrome Element Information Collection Form in Traditional Chinese Medicine;TCM Constitution Questionnaire;transcriptomics assays;proteomics assays;

Secondary

MeasureTime frame
Blood routine examination;Liver function(AST/ALT);Myocardial enzyme(UA/Cr/Urea);bloodlipid(TC/TG/HDL-C/LDL-C);Fasting Blood Glucose;Routine urine examination;

Countries

China

Contacts

Public ContactYang Le

The Second Affiliated Hospital Guangzhou University of Traditional Chinese Medicine

leyang92gzy@sina.com+86 186 4512 6685

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026