Chronic kidney disease
Conditions
Interventions
DM02 group:Probiotic DM02 (Lactobacillus rhamnosus) intervention for 4 weeks
placebo group :Placebo intervention for 4 weeks
Sponsors
The First Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age range: 45-65 years old (2) The diagnosis of patients with chronic kidney disease meets the criteria of CKD3-5 stage (eGFR<60ml/(min. 1.73m^2) in the "Guidelines for Early Screening, Diagnosis, and Prevention of Chronic Kidney Disease (2022 Edition)"
Exclusion criteria
Exclusion criteria: (1) Combined with serious diseases such as heart failure, myocardial infarction, dialysis, and acute kidney injury. (2) Combined with gastrointestinal diseases such as ulcerative colitis. (3) History of major gastrointestinal surgeries (such as subtotal gastrectomy) within the past five years (4) Recently taken antibiotics or probiotic preparations (5) Vulnerable groups such as the elderly, pregnant women, and children (6) Complicated with infectious diseases, with obvious abnormalities in blood routine, procalcitonin and C-reactive protein
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| abundance of Escherichia coli;CKD progresses or transitions to end-stage CKD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma indoxyl sulfate;All-cause death;All-cause hospitalization; | — |
Countries
China
Contacts
Public ContactYue Li
the First Affiliated Hospital of Harbin Medical University
Outcome results
None listed