Patellofemoral Osteoarthritis
Conditions
Interventions
Experimental group:Intra-articular injection of umbilical cord blood mononuclear cells into the knee joint cavity
Control group:Intra-articular injection of sodium hyaluronate into the knee joint cavity
Sponsors
Liaocheng People's Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age >=30 years and <=70 years, regardless of gender. 2.Meet the diagnostic criteria for patellofemoral osteoarthritis (PFOA) as outlined in the Chinese Guidelines for the Diagnosis and Treatment of Patellofemoral Joint Disorders (2020 Edition). 3.Grade I-III patellofemoral osteoarthritis based on MRI classification. 4.No knee surgery within 6 months prior to enrollment. 5.For patients with diabetes, blood glucose levels must be well-controlled. 6.Subjects and their families must understand the clinical trial protocol, agree to participate, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Known or suspected history of allergy, severe adverse reactions, or allergic predisposition to the investigational cells. 2.Patients with infectious arthritis or skin diseases around the knee. 3.Intra-articular drug injections in the target knee within the past 4 months. 4.Severe effusion due to rheumatoid arthritis, or patients who have undergone arthroscopic surgery or joint lavage within the past 6 months. 5.Severe patellofemoral osteoarthritis (MRI grade 4), patellofemoral dislocation, or habitual patellofemoral dislocation. 6.Patients with blood disorders such as coagulation abnormalities. 7.Patients with malignant tumors. 8.Severe cardiac or pulmonary dysfunction. 9.Active infections such as HBV, HCV, or HIV. 10.Poor compliance or psychiatric disorders. 11.Participation in other clinical trials within 1 month prior to enrollment or ongoing participation. 12.Women who are breastfeeding, pregnant, or planning to become pregnant. 13.Patients deemed unsuitable for enrollment by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (International Knee Documentation Committee Score;Visual Analog Scale Score;Kujala Score;Western Ontario and McMaster Universities Osteoarthritis Index Score;Lysholm Score; | — |
Countries
China
Contacts
Public ContactChengzhi Ha
Liaocheng People's Hospital
Outcome results
None listed