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Effect of furosemide under significant irrigation fluid absorption and hyperchloremic acidosis on renal function and clinical outcomes in patients undergoing transurethral resection of prostate (TURP)

Effect of furosemide under significant irrigation fluid absorption and hyperchloremic acidosis on renal function and clinical outcomes in patients undergoing transurethral resection of prostate (TURP) - Furosemide and acute kidney injury after TURP

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500100563
Enrollment
Unknown
Registered
2025-04-10
Start date
2025-04-15
Completion date
Unknown
Last updated
2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transurethral resection of prostate (TURP)

Interventions

Group 1:With diuretics
Group 2:Without diuretics

Sponsors

Lanzhou University Second Hospital & Second Clinical Medical College
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
40 Years to 100 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age >= 40 years old, undergoing elective TURP surgery (bipolar/laser mode). Preoperative renal function was normal (eGFR >= 60 mL/min/1.73m^2, Scr = 1000 mL (monitored by ESMS method).

Exclusion criteria

Exclusion criteria: Exclusion criteria: Preoperative heart failure (NYHA III-IV), cirrhosis, chronic kidney disease (CKD >= stage 3). Use other diuretics or nephrotoxic drugs during surgery. Intraoperative complications: massive bleeding (blood loss >= 1000 mL) or emergency transfer to open surgery.

Design outcomes

Primary

MeasureTime frame
Absorbent dose of irrigation fluid;Blood loss;Plasma sodium level;Plasma chloride level;Creatinine;Urea nitrogen;Cystatin C;Glomerular filtration rate;Irrigation fluid dosage;Hospital stay;Albumin;Base excess;—

Secondary

MeasureTime frame
pH;Bicarbonate;Lactic acid;Hemoglobin;Prostate volume;Prostate resection weight;—

Countries

China

Contacts

Public ContactHaitao Jia

Lanzhou University Second Hospital & Second Clinical Medical College

jiahaitao9@163.com+86 152 1409 7759

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026