chemotherapy-induced peripheral neuropathy
Conditions
Interventions
Group A:Dexmedetomidine was continuously infused at 0.5 µg/kg 10 min before operation and then 0.4 µg/(kg·h) until 30 min before operation. PCIA was connected at the end of surgery. In group A, butorp
Group B:After continuous infusion of dexmedetomidine 0.5 µg / kg at 10 min before operation, it was maintained at 0.4 µg / ( kg · h ) until 30 min before operation. At the end of the operation, the in
Group N:Saline was pumped at the same speed. PCIA was connected at the end of the operation. In group B, the formula was 0.15 mg/kg butorphanol + ondansetron 16 mg.
Sponsors
Yunnan Provincial Tumor Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. patients who underwent modified radical mastectomy under elective general anesthesia; 2. patients who clearly had CIPN after preoperative neoadjuvant chemotherapy and whose symptoms did not subside were selected; 3. ASA grade I ~ III ; 4. Age> 18 years old.
Exclusion criteria
Exclusion criteria: 1. patients with diabetes; 2. patients with definite history of nervous system and mental system diseases before chemotherapy; 3. having a history of drug abuse or long-term opioid use; 4. patients with sinus bradycardia or heart block and ventricular dysfunction before surgery; 5. patients with severe liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective symptom outcome;Total Neuropathy Score clinical version;The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20-item scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| 2ml peripheral venous blood was collected to measure the inflammatory cytokines IL-6, TNF-a, IL-2, IL-10, IFN-?; | — |
Countries
China
Contacts
Public ContactLei Lequn/ Wang Zhonghui
Department of Anesthesiology, Yunnan Provincial Tumor Hospital, No.519, Kunzhou Road, Kunming City, Yunnan Province, China
Outcome results
None listed