Acute ischemic stroke
Conditions
Interventions
Hypothermia group:Hypothermic saline therapy
Normothermia group:Normothermic saline therapy
Sponsors
Guangdong Second Provincial General Hospital (Guangdong Provincial Emergency Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Age >=18 and =6 points before randomization. 6.According to the judgment of the clinician, the operation path is reasonable, and the operation and operation related instruments can reach the disease smoothly. 7.Patients or their guardians can understand the purpose of the trial, voluntarily participate and sign a written informed consent, and are capable of receiving clinical follow-up. 8. Prior to randomization, CTA, MRA, or DSA confirmed the presence of anterior circulatory large vessel occlusion (internal carotid artery or M1segment). 9.The symptoms are aggravated by recurrent cerebral infarction in the same drainage basin and/or the pathogenesis is caused by decreased blood perfusion.
Exclusion criteria
Exclusion criteria: 1.Pre stroke mRS>1 score. 2.There are acute infarcts in both cerebral hemispheres and/or anterior and posterior circulation. 3.NIHSS1.5, PT> 1 minute above the upper limit of normal, or heparin-related thrombocytopenia). 6.Patients with heart function of grade 1 or above, or with a clear history of acute or chronic heart dysfunction, are at greater risk of acute heart failure or fluid perfusion intolerance as determined by clinicians. 7. Severe heart, liver, kidney disease. 8.With malignant diseases such as malignant tumors, the expected survival time is less than 3 months. 9.Participating in other clinical trials, in the investigational phase or in the follow-up phase.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale (mRS) score at 90 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale (NIHSS score);Symptomatic intracranial hemorrhage rate;Mortality rate;Cerebral infarct volume;Recanalization success rate; | — |
Countries
China
Contacts
Public ContactZhixin Huang
Guangdong Second Provincial General Hospital (Guangdong Provincial Emergency Hospital)
Outcome results
None listed