gastric cancer
Conditions
Interventions
Case series:none
Sponsors
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Histologically or cytologically confirmed gastric adenocarcinoma prior to treatment, with imaging studies (contrast-enhanced CT/contrast-enhanced ultrasonography) confirming resectable locally advanced gastric cancer without distant metastasis (cT3-4, N0/+, M0; staging according to the 8th edition AJCC guidelines); 2. Abdominal contrast-enhanced CT scans performed both before neoadjuvant therapy and after neoadjuvant therapy (prior to surgery); 3. Underwent radical gastrectomy following neoadjuvant therapy (chemotherapy alone or chemotherapy combined with immunotherapy), with postoperative pathological confirmation of tumor response; 4. Complete clinical and pathological follow-up data [including essential postoperative tumor regression grade (TRG) assessment].
Exclusion criteria
Exclusion criteria: 1. Previous history of gastric surgery; 2. Prior to neoadjuvant therapy, the patient had a history of gastric cancer or other tumors with documented antitumor treatment; 3. Multiple gastric cancer (including two or more lesions); 4. The primary lesion could not be detected on enhanced CT images; 5. CT image quality is poor (serious artifact, poor gastric filling).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| area under the curve,AUC;true positive rate,TPR;true negative rate,TNR;accuracy;negative predictive value,NPV;positive predictive value,PPV;decision curve analysis,DCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival,OS;progression-free survival, PFS; | — |
Countries
China
Contacts
Public ContactChen Huang
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed