Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Group A: Experimental Group (MLCT):An additional daily supplement of 25g of medium- and long-chain triglycerides (MLCT), outside of regular meals, for a duration of 8 weeks.
Group B: Control Group (MCT+LCT):An additional daily supplement of 25g of medium-chain triglycerides (MCT) and long-chain triglycerides (LCT) mixed oil, outside of regular meals, for a duration of 8 w
Group C: Blank Control Group:No intervention.
Sponsors
The First Affiliated Hospital of Gannan Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients clinically diagnosed with Chronic Obstructive Pulmonary Disease (COPD), including stage II (moderate) and stage III (severe) patients (classified according to the Global Initiative for Chronic Obstructive Lung Disease, GOLD, and the COPD Diagnosis and Treatment Guidelines); 2. Clear signs of malnutrition, with a Body Mass Index (BMI) <= 17.5 kg/m² and physical wasting; 3. Age between 18 and 80 years, regardless of gender (according to data from the COPD monitoring survey of Chinese residents, the COPD prevalence in individuals over 40 years old in China is 13.6%, with 19.0% in men and 8.1% in women, rapidly increasing with age); 4. Good dietary status, with no history of binge eating, compensatory eating behavior, extreme dieting, or alcohol abuse; 5. The subject or their guardian has signed an informed consent form; 6. The subject has completed a written informed consent form and agrees to cooperate with the study throughout the entire trial period.
Exclusion criteria
Exclusion criteria: 1. Abuse of narcotics or psychoactive drugs within the past 6 months; 2. Pregnant or breastfeeding women, or those planning to become pregnant within the next 6 months; 3. Poor patient compliance and low likelihood of follow-up; 4. Severe liver dysfunction; 5. Expected survival time less than 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary function;6-minute walk test;BMI, body fat, muscle mass; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete blood count;Blood lipids;Blood glucose;Liver Function tests;Renal Function tests; | — |
Countries
China
Contacts
Public ContactJianrong Zhou
The First Affiliated Hospital of Gannan Medical University
Outcome results
None listed