Traumatic Brain Injury
Conditions
Interventions
Observation group:None
control group:None
Sponsors
The Third Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Diagnosed with traumatic brain injury (TBI) and a Glasgow Coma Scale (GCS) score of less than 15 upon admission; 3.Underwent neurosurgical intervention for TBI and received postoperative cerebrospinal fluid (CSF) drainage; 4.Enrollment within one week (7 days) after surgery; 5.Informed consent has been obtained from the patient or their legal representative for participation in the study. Control group: 1. Age>= 18 years old; 2. patients with non-traumatic head trauma undergoing subarachnoid anesthesia;3.With the consent of the affected party to participate in this experiment.
Exclusion criteria
Exclusion criteria: 1.Pregnant women, individuals under 18 years of age, or patients with end-stage diseases; 2.Patients with severe injuries in other body regions (Injury Severity Score [ISS] >= 3); 3.Patients with other neurological disorders (e.g., Alzheimer’s disease, multiple sclerosis); 4.Patients who have active infections, are recovering from recent infections, or have chronic inflammatory conditions; 5.Patients with immunodeficiency or autoimmune diseases; 6.Patients who underwent emergency surgery; 7.Patients or their legal representatives who decline to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Specialized Pro-Resolving Mediators Series;Glasgow Outcome Scale assessed at 3 months post-injury;Length of hospital stay;Inflammatory indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of ICU stay;Duration of mechanical ventilation; | — |
Countries
China
Contacts
Public ContactJie Chen
The Third Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed