postoperative delirium
Conditions
Interventions
Experimental group:Maintain PaCO2 : 46-50mmHg
Control group:Maintain PaCO2 : 35-45mmHg
Sponsors
Wuxi Second People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Age >= 65 years ASA Physical Status Classification II or III Surgical duration between 1–4 hours History of diabetes mellitus =3 years, with preoperative fasting blood glucose controlled =10 mmol/L Preoperative Mini-Mental State Examination (MMSE) score >27 Scheduled for laparoscopic surgery, with no surgical contraindications
Exclusion criteria
Exclusion criteria: Patients with elevated intracranial pressure (e.g., hydrocephalus, brain tumors, intracranial space-occupying lesions). Patients with severe vision or hearing impairment preventing effective communication. Preoperative moderate-to-severe anemia (hemoglobin <90 g/L). Patients undergoing emergency surgery or procedures converted to open surgery intraoperatively. Patients with preexisting psychiatric disorders. Patients with severe arrhythmias, cardiac/hepatic/renal failure, or other major organ dysfunction. Preoperative arterial oxygen partial pressure (PaO2) <60 mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Postoperative Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;phosphorylated Tau-217 protein;S100ß protein;Postoperative Blood Glucose;VAS score; | — |
Countries
China
Contacts
Public ContactHuang Dongxiao
Wuxi Second People's Hospital
Outcome results
None listed