The effect of Methylprednisolone on rebound pain following nerve block in ankle surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500100487

Enrollment

Unknown

Registered

2025-04-10

Start date

2025-04-14

Completion date

Unknown

Last updated

2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rebound pain after nerve block

Interventions

Dexamethasone group:Inject 20 ml of 0.375% ropivacaine (containing 8 mg of dexamethasone) around the sciatic nerve on the affected side.

Methylprednisolone group:Inject 20 ml of 0.375% ropivacaine (containing 40 mg of methylprednisolone) around the sciatic nerve on the affected side.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for foot and ankle surgery 2. Patients with ASA physical status classification I - III 3. Patients aged 18 - 75 years 4. Patients with a BMI of 19.6 - 29.9 kg/m²

Exclusion criteria

Exclusion criteria: 1. The patient refuses. 2. Severe hematological diseases. 3. Simultaneous bilateral limb surgery. 4. Contraindications to nerve block (such as coagulation disorders, local anesthetic allergy or local infection). 5. Contraindications to corticosteroids (peptic ulcer disease, systemic infection, glaucoma, active varicella/herpes zoster infection, diabetes). 6. Pregnant or breastfeeding women. 7. Peripheral neuropathy. 8. Long-term use of opioid drugs and a history of drug addiction. 9. Cognitive impairment. 10. Contraindications to general anesthesia.

Design outcomes

Primary

Measure	Time frame
The incidence of rebound pain;Rebound pain score;Time of rebound pain occurrence;Incidence of postoperative nausea and vomiting in four groups ;	—

Secondary

Measure	Time frame
Duration of sensory block;Duration of motor block;Pain scores during movement and at rest before and after surgery;Sleep quality;The need for postoperative rescue analgesics;Quality of postoperative recovery;Intraoperative adverse events (bradycardia, hypotension, hypertension), postoperative adverse events (pruritus, dizziness, respiratory depression), and the incidence of surgical site infection.;The incidence of chronic pain and the recovery of lower limb function;Scores on the pain sensitivity scale and pain catastrophizing scale;Patient satisfaction score;Postoperative blood glucose values;	—

Measure

Time frame

Duration of sensory block;Duration of motor block;Pain scores during movement and at rest before and after surgery;Sleep quality;The need for postoperative rescue analgesics;Quality of postoperative recovery;Intraoperative adverse events (bradycardia, hypotension, hypertension), postoperative adverse events (pruritus, dizziness, respiratory depression), and the incidence of surgical site infection.;The incidence of chronic pain and the recovery of lower limb function;Scores on the pain sensitivity scale and pain catastrophizing scale;Patient satisfaction score;Postoperative blood glucose values;

—

Countries

China

Contacts

Public ContactFang Kang

The First Affiliated Hospital of China USTC

kangfang199771@163.com+86 181 5512 7799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026