Mild Cognitive Impairment
Conditions
Interventions
Control Group:Computerized cognitive training combined with micro-odor stimuli
Intervention Group:Computerized cognitive training combined with pleasant odor stimulation
Sponsors
Peking University Sixth Hospital ( Institute of Mental Health )
Eligibility
Sex/Gender
All
Age
55 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Voluntary participation;Ability to understand and sign an informed consent form;Right-handed; 2.55 years of age or older, regardless of sex; 3.Elementary school education or higher (>=5 years of education); 4.The Petersen MCI diagnostic criteria were met: (1). Memory loss confirmed by the informant; (2). Evidence of objective cognitive impairment (MoCA 17 points for those with elementary school education, and >=24 points for those with junior high school education or above); (4). Ability to lead daily life basically normal (ADL <=26 points); and e. Did not meet the diagnostic criteria for dementia (according to ICD-10 and NINCDS-ADRDA) and have an overall Global CDR score of 0.5; 5.Hamilton Depression (HAMD) score <=7;
Exclusion criteria
Exclusion criteria: 1.Current use of anti-dementia medication (e.g. donepezil hydrochloride, memantine tablets, carboplatin, lencanelizumab, etc.); 2.Those with other conditions that affect olfactory function such as chronic rhinitis, allergic rhinitis, nasal polyps, and a history of upper respiratory tract infection in the last two weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Delayed Paired Recall Change Values for Memory Binding Tests; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in overall cognitive function;Changes in olfactory function;Neuroimaging changes;Changes in mood; | — |
Countries
China
Contacts
Public ContactYu xin
Peking University Sixth Hospital ( Institute of Mental Health )
Outcome results
None listed