Colorectal cancer manifested as dMMR by immunohistochemistry or MSI - H by PCR
Conditions
Interventions
Case series:None
Sponsors
The First Affiliated Hospital Of Zhengzhou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Immunohistochemistry shows dMMR or PCR reveals MSI-H. 2. Pathological examination confirms the diagnosis of colorectal cancer. 3. Complete endoscopic and imaging data are available. 4. The clinical tumor stage is II-III. 5. Radical surgery has been performed. 6. Neoadjuvant immunotherapy with PD-1 inhibitor monotherapy has been adopted
Exclusion criteria
Exclusion criteria: 1. Colorectal cancer with pMMR (mismatch repair proficient). 2. Distant metastasis detected before or during the operation. 3. Emergency surgery is required due to intestinal obstruction, intestinal perforation, etc. caused by the tumor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pathologic complete response, PCR; | — |
Secondary
| Measure | Time frame |
|---|---|
| Organ retention rate;Adverse reactions;3-year overall survival;3-year disease-free survival; | — |
Countries
China
Contacts
Public ContactYugui Lian
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed