Abdominal Surgery in the Elderly
Conditions
Interventions
Ketamine combined with oxycodone combination group(Group SO):Intravenous injection of oxycodone injection is administered 30 minutes before the end of the surgery. Meanwhile, esketamine is intravenous
Oxycodone group (C):Administer Oxycodone Hydrochloride Injection 30 minutes before the end of the surgery. At the same time, intravenously pump an equal dose of normal saline as that of esketamine. Af
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The operation time is more than 2 hours; 2. 65 years old<= age <= 80 years old; 3: ASA I-III; 4: BMI<30;
Exclusion criteria
Exclusion criteria: 1: Chronic cardiovascular or respiratory diseases; 2: Combined with severe organic or metabolic diseases such as liver and kidney; 3: Surgical contraindications or allergies to anesthetic drugs; 4: Long-term history of chronic pain, long-term use of analgesics, long-term drug abuse and alcoholism; 5: Language barriers, or patients who are unable to use PCA (intellectual disability, disorientation, Alzheimer's disease, etc.); 6: Weight less than 40kg; 7: History of Schizophrenia,epilepsy or myasthenia gravis; 8: Combined with hyperthyroidism or pheochromocytoma; 9: Other conditions deemed unsuitable for participation in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of moderate to severe pain within 72 hours postoperatively (NRS>=4); | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain intensity;Sleep quality;Agitation score (RS score);Sedation score (Ramsay score); | — |
Countries
China
Contacts
Public ContactYing Sun
Tianjin First Central Hospital
Outcome results
None listed