Acute posterior circulation large vessel occlusion stroke
Conditions
Interventions
Glucocorticoids group:NA
Control:
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Initially diagnosed with acute ischemic stroke based on clinical symptoms or imaging examination; 3. Posterior circulation large vessel occlusion confirmed by CTA/MRA/DSA, with a decision for endovascular treatment; 4. NIHSS score > 5; 5. Received or did not receive glucocorticoid treatment; 6. Written informed consent signed by the patient or their family.
Exclusion criteria
Exclusion criteria: 1. Intracranial hemorrhage confirmed by cranial CT or MRI; 2. Pre-stroke mRS score >= 2; 3. Pregnant or lactating women; 4. Allergy to contrast agents; 5. Allergy to glucocorticoids; 6. Participation in other clinical trials; 7. Systolic blood pressure > 185 mmHg or diastolic blood pressure > 110 mmHg, uncontrolled by oral antihypertensive medication; 8. Genetic or acquired bleeding disorders, coagulation factor deficiency, or oral anticoagulation with INR > 1.7; 9. Blood glucose 22.2 mmol/L (400 mg/dl); 10. Arterial tortuosity preventing thrombectomy device from reaching the target vessel; 11. History of bleeding (gastrointestinal or urinary tract) within the past month; 12. Chronic hemodialysis or severe renal insufficiency (glomerular filtration rate 220 µmol/L (2.5 mg/dl)); 13. Any terminal illness with an expected survival of < 6 months; 14. Inability to complete follow-up; 15. Intracranial aneurysm or arteriovenous malformation; 16. Space-occupying brain tumor on imaging; 17. Macular edema; 18. Mobitz type II second-degree/third-degree atrioventricular block, sick sinus syndrome, or related medical history; 19. Systemic infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90-day mortality;Incidence of symptomatic intracranial hemorrhage (SICH) within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day global Outcome Score;The proportion of mRS score of 0–1 at 90 days;The proportion of mRS score of 0–2 at 90 days;The change of the NlHSS score at 5-7 days or discharge if earlier from baseline;European Quality of Life Five-Dimension scale at 90+7 days; | — |
Countries
China
Contacts
Public ContactWenjie Zi
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed