Optic Neuritis
Conditions
Interventions
Treatment group:Scheduled injection of Secukinumab
Sponsors
Chinese People's Liberation Army General Hospital
Eligibility
Sex/Gender
All
Age
8 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1, Age >=8 years old, and <=65 years old; 2. The clinical diagnosis was recurrent MOG-Ab positive ON; 3. Positive for MOG-Ab in Serum detected by CBA method (titer over 1:10 considered positive); 4. Patients can sign informed consent by themselves
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Patients who have used other biologics (including Rituximab) within 3 months prior to the current onset of illness; 3. Patients with a recent plan for vaccination; 4. Heart disease; 5. Infectious diseases; 6. White blood cell count 14000 × 10^9/L before corticosteroid therapy during the acute phase; 7. Participants considered unsuitable for this clinical trial for other reason
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The interval between disease relapses; | — |
Secondary
| Measure | Time frame |
|---|---|
| vision;Optical Coherence Tomography;Peripheral Blood T-cell Detection; | — |
Countries
China
Contacts
Public ContactShihui Wei
Chinese People's Liberation Army General Hospital
Outcome results
None listed